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soleus

10/30，在放射药物领域融资和交易活跃的十月，Blue Earth Therapeutics于周三成功筹集了7650万美元的A轮融资，以推动其针对前列腺癌的放射配体疗法（RLT）组合的开发。该公司旨在通过开发具有“放射混合”PSMA配体的化合物，将其𐄧𚿥‘射体铥（177Lu）和𐄧𚿥‘射体锕（225Ac）项目与第一代PSMA靶向RLTs区分开来。 Blue Earth改进的连接器包括一个羧酸侧链和一个SiFa基团，以改善白蛋白结合、整体电荷、内化和滞留，目标是与现有RLTs相比，优化生物分布和清除。首席执行官David Gauden表示：“通过新投资者和我们组建的团队，我们现在拥有了出色的专业知识组合和资源，以推进我们的使命，开发放射配体疗法，有潜力通过向肿瘤提供高辐射剂量而不损害正常器官安全来改善患者结果。” 此次融资由Soleus Capital主导，Sands Capital Management共同领导，将帮助Blue Earth启动其两个治疗项目的2期临床研究。现有投资者Bracco Imaging SpA也参与了此次融资，还有新投资者Woodline Partners和PBM Capital。 Blue Earth的资本筹集延续了本月放射药物领域的积极趋势，此前，赛诺菲对Orano Med进行了3亿欧元的股权投资，后者正在开发具有铅-212负载的RLTs。同样在十月，Alpha-9 Oncology完成了1.75亿美元的C轮融资，以推进其灵活的RLT管线，Telix Pharmaceuticals则将其Rhine Pharma子公司剥离出来，以开发携带发生器生产同位素（如铼-188Re）的RLTs。Nucleus RadioPharma还宣布计划在美国建设两个新的RLT制造工厂。网页链接

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